Product Description

TASK-1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES8371-50, ES8371-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: KCNK3, TASK, TASK1, Potassium channel subfamily K member 3, Acid-sensitive potassium channel protein TASK-1, TWIK-related acid-sensitive K(+) channel 1, Two pore potassium channel KT3.1, Two pore K(+) channel KT3.1

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human TASK-1. AA range:47-96

Isotype: IgG

Target: TASK-1

Specificity: TASK-1 Polyclonal Antibody detects endogenous levels of TASK-1 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Widespread expression in adult, Strongest expression in pancreas and placenta, Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon,

Observed Band (KD): 53kD

Fields: Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome

Function: Function: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward
Miscellaneous: Inhibited by external acidification. Activated by halothane and isoflurane
Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family
Tissue Specificity: Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon

Subcellular Location: Cell membrane, Multi-pass membrane protein

Storage and Stability: -20°C/1 year

Gene Name: KCNK3

Protein Name: Potassium channel subfamily K member 3

Mouse Gene ID: 16527

Mouse SwissProt Number: O35111

Rat Gene ID: 29553

Rat SwissProt Number: O54912

Research Use Only