Product Description

Tau (Phospho-Ser396) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES8880-50, ES8880-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)

Clonality: Polyclonal

Immunogen: Synthesized phospho derived from human Tau (Phospho-Ser396)

Isotype: IgG

Target: Tau

Specificity: This detects endogenous levels of Tau (Phospho-Ser396)

Dilution: WB 1:500-2000, ELISA 1:10000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in neurons, Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system,

Observed Band (KD): 50-85kD

Fields: MAPK signaling pathway, Alzheimer disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases

Function: Alternative Products: Additional isoforms seem to exist. Isoforms differ from each other by the presence or absence of up to 5 of the 15 exons. One of these optional exons contains the additional tau/MAP repeat,Developmental Stage: Four-repeat (type II) tau is expressed in an adult-specific manner and is not found in fetal brain, whereas three-repeat (type I) tau is found in both adult and fetal brain
Disease: Defects in MAPT are a cause of corticobasal degeneration (CBD). It is marked by extrapyramidal signs and apraxia and can be associated with memory loss. Neuropathologic features may overlap Alzheimer disease, progressive supranuclear palsy, and Parkinson disease
Disease: Defects in MAPT are a cause of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP17) [MIM: 600274, 172700], also called frontotemporal dementia (FTD) or historically termed Pick complex. This form

Subcellular Location: Cytoplasm, cytosol Cell membrane, Peripheral membrane protein, Cytoplasmic side Cytoplasm, cytoskeleton Cell projection, axon Cell projection, dendrite Secreted Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components (PubMed:10747907) Can be secreted, the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10, it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059)

Storage and Stability: -20°C/1 year

Gene Name: MAPT MAPTL MTBT1 TAU

Protein Name: Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)

Mouse Gene ID: 17762

Mouse SwissProt Number: P10637

Rat SwissProt Number: P19332

Research Use Only