Product Description

TEFF2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10934-50, ES10934-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: TEFF2

Specificity: TEFF2 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Highly expressed in adult and fetal brain, spinal cord and prostate, Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum, Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa, Expressed in prostate carcinoma, Down-regulated in colorectal cancer, Present in Alzheimer disease plaques (at protein level), Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate,

Observed Band (KD): 41kD

Function: Function: May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation
Induction: Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines
PTM: A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or proinflammatory cytokines such as TNFalpha, and is mediated by ADAM17
PTM: N-glycosylated. Contains chondroitin sulfate glycosaminoglycans
Sequence Caution: Contaminating sequence. Mitochondrial contamination starting in position 361
Similarity: Belongs to the tomoregulin family
Similarity: Contains 1 EGF-like domain
Similarity: Contains 2 Kazal-like domains
Tissue Specificity: Highly expressed in adult and feta

Subcellular Location: [Isoform 1]: Membrane, Single-pass type I membrane protein, [Isoform 2]: Membrane, Single-pass type I membrane protein, [Isoform 3]: Secreted

Storage and Stability: -20°C/1 year

Gene Name: TMEFF2 HPP1 TENB2 TPEF UNQ178/PRO204

Protein Name: Tomoregulin-2 (TR-2) (Hyperplastic polyposis protein 1) (Transmembrane protein with EGF-like and two follistatin-like domains)

Mouse SwissProt Number: Q9QYM9

Research Use Only