Product Description

Tensin-1 (phospho Tyr1326) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1531-50, ES1531-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Alternate Names: TNS1, TNS, Tensin-1

Clonality: Polyclonal

Immunogen: Synthesized phospho-peptide around the phosphorylation site of human Tensin-1 (phospho Tyr1326)

Isotype: IgG

Target: Tensin-1

Specificity: Phospho-Tensin-1 (Y1326) Polyclonal Antibody detects endogenous levels of Tensin-1 protein only when phosphorylated at Y1326.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitous,

Observed Band (KD): 185kD

Function: Function: May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton
PTM: Rapidly cleaved by calpain II
PTM: Tyrosine phosphorylated
Similarity: Contains 1 C2 tensin-type domain
Similarity: Contains 1 phosphatase tensin-type domain
Similarity: Contains 1 SH2 domain
Subunit: Binds to actin filaments and interacts with phosphotyrosine-containing proteins. Interacts with STARD8
Tissue Specificity: Ubiquitous

Subcellular Location: Cell surface Cell junction, focal adhesion Cytoplasm, cytoskeleton Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner

Storage and Stability: -20°C/1 year

Gene Name: TNS1

Protein Name: Tensin-1

Research Use Only