Product Description

TFPI Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES3965-50, ES3965-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: TFPI, LACI, TFPI1, Tissue factor pathway inhibitor, TFPI, Extrinsic pathway inhibitor, EPI, Lipoprotein-associated coagulation inhibitor, LACI

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the C-terminal region of human TFPI. AA range:251-300

Isotype: IgG

Target: TFPI

Specificity: TFPI Polyclonal Antibody detects endogenous levels of TFPI protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Mostly in endothelial cells,

Observed Band (KD): 34kD

Fields: Complement and coagulation cascades

Function: Domain: This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa
Function: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma
Online Information: TFPI entry,PTM: O-glycosylated
Similarity: Contains 2 BPTI/Kunitz inhibitor domains
Similarity: Contains 3 BPTI/Kunitz inhibitor domains
Tissue Specificity: Mostly in endothelial cells

Subcellular Location: [Isoform Alpha]: Secreted, [Isoform Beta]: Microsome membrane, Lipid-anchor, GPI-anchor

Storage and Stability: -20°C/1 year

Gene Name: TFPI

Protein Name: Tissue factor pathway inhibitor

Mouse SwissProt Number: O54819

Research Use Only