Product Description

TLE3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES12682-50, ES12682-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human TLE3 AA range: 257-307

Isotype: IgG

Target: TLE3

Specificity: This antibody detects endogenous levels of TLE3 at Human/Mouse/Rat

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.343% sodium azide.

Expression: Placenta and lung,

Observed Band (KD): 85kD

Fields: Wnt signaling pathway, Notch signaling pathway

Function: Alternative Products: Experimental confirmation may be lacking for some isoforms,Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES
Similarity: Belongs to the WD repeat Groucho/TLE family
Similarity: Contains 7 WD repeats
Subunit: Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1 and TCF7L2 (By similarity). Binds FOXA2
Tissue Specificity: Placenta and lung

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: TLE3 KIAA1547

Protein Name: TLE3

Mouse Gene ID: 21887

Mouse SwissProt Number: Q08122

Rat Gene ID: 84424

Rat SwissProt Number: Q9JIT3

Research Use Only