Product Description

TNF-β Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES3624-50, ES3624-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012],

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Applications: WB, ELISA

Alternate Names: LTA, TNFB, TNFSF1, Lymphotoxin-alpha, LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human TNF-beta. AA range:17-66

Isotype: IgG

Target: TNFB

Specificity: TNF-β Polyclonal Antibody detects endogenous levels of TNF-β protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Lymph, Peripheral blood leukocyte, Peripheral blood mononuclear cells, Peripheral blood mononu

Observed Band (KD): 22kD

Fields: Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, TNF signaling pathway, Type I diabetes mellitus, Human T-cell leukemia virus 1 infection, Herpes simplex virus 1 infection

Function: Disease: Genetic variations in LTA are associated with susceptibility to leprosy type 4 (LPRS4) [MIM: 610988], also known as susceptibility to age-dependent leprosy. Leprosy is a chronic infectious disease of peripheral sensory nerves caused by Mycobacterium leprae
Disease: Genetic variations in LTA are associated with susceptibility to psoriatic arthritis [MIM: 607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. Psoriatic arthritis has been defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative arthritis) associated with psoriasis
Function: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its hetero

Subcellular Location: Secreted Membrane The homotrimer is secreted The heterotrimer is membrane-associated

Storage and Stability: -20°C/1 year

Gene Name: LTA

Protein Name: Lymphotoxin-alpha

Mouse Gene ID: 16992

Mouse SwissProt Number: P09225

Rat Gene ID: 25008

Rat SwissProt Number: Q06332

Research Use Only