Product Description

TNF-IP 8 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES3621-50, ES3621-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: developmental stage:Expressed at high levels in the fetal liver, lung and kidney.,function:Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.,induction:By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB.,similarity:Belongs to the TNFAIP8 family.,tissue specificity:Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.,

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: TNFAIP8, Tumor necrosis factor alpha-induced protein 8, TNF alpha-induced protein 8, Head and neck tumor and metastasis-related protein, MDC-3.13, NF-kappa-B-inducible DED-containing protein, NDED, SCC-S2, TNF-induced protein GG2-1

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human TFIP8. AA range:31-80

Isotype: IgG

Target: TNF-IP 8

Specificity: TNF-IP 8 Polyclonal Antibody detects endogenous levels of TNF-IP 8 protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta, Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells, Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle,

Observed Band (KD): 23kD

Function: Developmental Stage: Expressed at high levels in the fetal liver, lung and kidney
Function: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation
Induction: By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB
Similarity: Belongs to the TNFAIP8 family
Tissue Specificity: Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle

Subcellular Location: Cytoplasm

Storage and Stability: -20°C/1 year

Gene Name: TNFAIP8

Protein Name: Tumor necrosis factor alpha-induced protein 8

Mouse Gene ID: 106869

Mouse SwissProt Number: Q921Z5

Research Use Only