Product Description

TORC1/CRTC1 (phospho-Ser151) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES12606-50, ES12606-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB

Alternate Names: CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1)

Clonality: Polyclonal

Immunogen: Synthesized phosho peptide around human TORC1 and CRTC1 (Ser151)

Isotype: IgG

Target: TORC1

Specificity: This antibody detects endogenous levels of Human TORC1 or CRTC1 (phospho-Ser151)

Dilution: WB 1:1000-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Highly expressed in adult and fetal brain, Located to specific regions such as the prefrontal cortex and cerebellum, Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney,

Observed Band (KD): 70kD

Fields: Human T-cell leukemia virus 1 infection

Function: Disease: A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11, 19)(q21, p13) with MAML2. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas
Function: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator

Subcellular Location: Cytoplasm Nucleus Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (PubMed:16817901) Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels (PubMed:15589160) Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain (By similarity)

Storage and Stability: -20°C/1 year

Gene Name: CRTC1 KIAA0616 MECT1 TORC1 WAMTP1

Protein Name: TORC1/CRTC1 (Ser151)

Mouse Gene ID: 382056

Mouse SwissProt Number: Q68ED7

Rat Gene ID: 684527

Rat SwissProt Number: Q157S1

Research Use Only