Product Description

TRAF1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES8493-50, ES8493-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: TNF receptor associated factor 1(TRAF1) Homo sapiens The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins, this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Alternate Names: TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from TRAF1 at AA range: 191-240

Isotype: IgG

Target: TRAF1

Specificity: TRAF1 Polyclonal Antibody detects endogenous levels of TRAF1

Dilution: WB 1:500-2000, ELISA 1:10000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Lymphoma, Skin, Spleen, Stomach,

Observed Band (KD): 46kD

Fields: NF-kappa B signaling pathway, Apoptosis, TNF signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, Small cell lung cancer

Function: Domain: The coiled coil domain mediates homo- and hetero-oligomerization
Domain: The MATH/TRAF domain binds to receptor cytoplasmic domains
Function: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and JNK and is involved in apoptosis. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2
Similarity: Contains 1 MATH domain
Subunit: Homotrimer (Probable). Heteromer with TRAF2 and associates with TNFRSF1B/TNFR2 through TRAF2. Associates with TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP and RIPK2. Interacts with BIRC2 and BIRC3

Subcellular Location: cytoplasm, cytosol,

Storage and Stability: -20°C/1 year

Gene Name: TRAF1

Protein Name: TRAF1

Mouse Gene ID: 22029

Mouse SwissProt Number: P39428

Research Use Only