Transgelin/TAGLN Rabbit PolymAb®
Sizes: 20μL, 100μL
Catalogue Numbers: A25499PM-20, A25499PM-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization.
Category: Monoclonal Antibodies
Applications: WB, IF-P, IHC-P, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 23kDa
Observed Molecular Weight: 23kDa
Immunogen: Synthetic peptide .
Species: Human
GeneID: 6876
SWISS: Q01995
Alternate Names: SM22; SMCC; TAGLN1; WS3-10; SM22-alpha
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide, 0.05% BSA, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:6500 - 1:26000 IF-P, 1:200 - 1:800 IHC-P, 1:5000 - 1:20000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Cytoskeleton, Microfilaments, Neuroscience, Calcium Signaling, Cardiovascular, Heart, Contractility.
NCBI Alias: TAGLN
Research Use Only