Tryptase α/β1 Polyclonal Antibody-BS91380

Tryptase α/β1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91380-50, BS91380-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q15661(Human) Q02844(Mouse) P27435(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IP,

All Applications: WB:1:1,000-1:5,000
IHC:1:50-1:200

Background: Mast cells are connective tissue cells derived from blood-forming tissues that line arterial walls and secrete substances, which mediate inflammatory and immune responses. Mast cell chymase, known as CMA1, is a major secreted serine protease that is involved in vasoactive peptide generation, extracellular matrix degradation and regulation of gland secretion. The human chymase gene, which maps to human chromosome 14q11.2, encodes a preproenzyme with a 19-amino acid signal peptide, an acidic 2-amino acid propeptide and a 226-amino acid catalytic domain. Tryptases comprise a family of trypsin-like serine proteases that are enzymatically active as heparin-stabilized tetramers. There are four functional genes for tryptase: α I, β I, β II and γ I, which map to human chromosome 16p13.3, with β tryptases representing the main isoenzymes expressed in mast cells. Mast cell proteases are a family of rodent protein homologs to human tryptases that are specifically expressed in mast cells and may serve as highly specific markers in the analysis of mast cell heterogeneity, differentiation and function.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Tryptase α/β1 polyclonal antibody detects endogenous levels of Tryptase α/β1 protein.

Bioworld Molecular Weight: 30 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Mast Cell Tryptase on human skin lysates using anti-Mast Cell Tryptase antibody at 1/1,000 dilution., Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Mast Cell Tryptase antibody. Counter stained with hematoxylin.

Alternative Name: Tryptase-1, TPSAB1, alpha II, Lung tryptase, Mast cell alpha II tryptase, Mast cell beta I tryptase, Mast cell protease 7, Mast cell protease II, MCP 7, Pituitary tryptase, Skin tryptase, TPS 1, TPS1, TPS2, TPSAB1, TPSAB1 protein, TPSB1, Tryptase 1, Tryptase alpha 1, tryptase alpha I included, Tryptase alpha II, tryptase alpha II included, tryptase alpha included, tryptase alpha/beta 1, Tryptase beta 1, tryptase beta I included, Tryptase I, tryptase I included, Tryptase III, Tryptase skin,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified