Product Description

Tubulin α-3C/D/E Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES3655-50, ES3655-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene is an alpha tubulin gene that encodes a protein 99% identical to the mouse testis-specific Tuba3 and Tuba7 gene products. This gene is located in the 13q11 region, which is associated with the genetic diseases Clouston hidrotic ectodermal dysplasia and Kabuki syndrome. [provid

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: TUBA3C, TUBA2, TUBA3D, Tubulin alpha-3C/D chain, Alpha-tubulin 2, Alpha-tubulin 3C/D, Tubulin alpha-2 chain, TUBA3E, Tubulin alpha-3E chain, Alpha-tubulin 3E

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human TUBA3C/E. AA range:201-250

Isotype: IgG

Target: Tubulin α-3C/D/E

Specificity: Tubulin α-3C/D/E Polyclonal Antibody detects endogenous levels of Tubulin α-3C/D/E protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Epithelium, Skin, Testis,

Observed Band (KD): 50kD

Function: Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain
Online Information: Tubulin entry,PTM: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively
Similarity: Belongs to the tubulin family
Subunit: Dimer of alpha and beta chains
Tissue Specificity: Testis specific

Subcellular Location: nucleus, cytoplasm, microtubule,

Storage and Stability: -20°C/1 year

Gene Name: TUBA3C/D/TUBA3E

Protein Name: Tubulin alpha-3C/D chain/Tubulin alpha-3E chain

Research Use Only