TXNRD1 Polyclonal Antibody Sizes: 60μL, 120μL, 200μL Catalogue Numbers: E-AB-66881-60, E-AB-66881-120, E-AB-66881-200 Citations, Manuals and MSDS Available upon request. Abbreviation: TXNRD1 Target Synonym: TXNRD1; GRIM-12; TR; TR1; TRXR1; TXNR Research Areas: Signal Transduction,Cell Biology,Metabolism Conjugation: Unconjugated Host: Rabbit Species Reactivity: Human, Mouse, Rat Application: IHC, IF Isotype: IgG Clonality: Polyclonal UNIProt ID: Q16881 Background: This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. Concentration: 1mg/mL Immunogen: Recombinant protein of human TXNRD1 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Purification Method: Affinity purification Dilution: IHC 1:50-1:100 IF 1:50-1:200 Storage: -20°C/One year. Avoid freeze / thaw cycles. Shipping: Ice bag Research Use Only