UCP1 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A18853-20, A18853-100
Citations, Manuals and MSDS Available upon request.
Background: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Mouse
Protein Weight: 33kDa
Observed Molecular Weight: 30kDa
Immunogen: Synthetic peptide .
Species: Pig
GeneID: 281561
SWISS: P10861
Alternate Names: Mitochondrial brown fat uncoupling protein 1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction, Metabolism, Mitochondrial, Types of disease, Obesity, Cancer.
NCBI Alias: UCP1
Research Use Only