Product Description

UCP3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES3672-50, ES3672-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression, this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria.

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: UCP3, SLC25A9, Mitochondrial uncoupling protein 3, UCP 3, Solute carrier family 25 member 9

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human UCP3. AA range:259-308

Isotype: IgG

Target: UCP3

Specificity: UCP3 Polyclonal Antibody detects endogenous levels of UCP3 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Only in skeletal muscle and heart, Is more expressed in glycolytic than in oxidative skeletal muscles,

Observed Band (KD): 33kD

Function: Disease: Defects in UCP3 may be involved in severe obesity [MIM: 601665]
Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance
Similarity: Belongs to the mitochondrial carrier family
Similarity: Contains 3 Solcar repeats
Tissue Specificity: Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles

Subcellular Location: Mitochondrion inner membrane, Multi-pass membrane protein

Storage and Stability: -20°C/1 year

Gene Name: UCP3

Protein Name: Mitochondrial uncoupling protein 3

Mouse Gene ID: 22229

Mouse SwissProt Number: P56501

Rat Gene ID: 25708

Rat SwissProt Number: P56499

Research Use Only