Product Description

Unc18-1 (phospho Ser313) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES7315-50, ES7315-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010],

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Applications: WB, ELISA

Alternate Names: STXBP1, UNC18A, Syntaxin-binding protein 1, MUNC18-1, N-Sec1, Protein unc-18 homolog 1, Unc18-1, Protein unc-18 homolog A, Unc-18A, p67

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human MUNC-18a around the phosphorylation site of Ser313. AA range:279-328

Isotype: IgG

Target: Unc18-1

Specificity: Phospho-Unc18-1 (S313) Polyclonal Antibody detects endogenous levels of Unc18-1 protein only when phosphorylated at S313.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain and spinal cord, Highly enriched in axons,

Observed Band (KD): 65kD

Fields: Synaptic vesicle cycle

Function: Disease: Defects in STXBP1 are the cause of early infantile epileptic encephalopathy type 4 (EIEE4) [MIM: 612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination
Function: May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1: 1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions
Similarity: Belongs to the STXBP/unc-18/SEC1 family
Subunit: Binds SYTL4 and STX1A
Tissue Specificity: Brain and spinal cord. Highly enriched in axons

Subcellular Location: Cytoplasm, cytosol Membrane, Peripheral membrane protein

Storage and Stability: -20°C/1 year

Gene Name: STXBP1

Protein Name: Syntaxin-binding protein 1

Mouse Gene ID: 20910

Mouse SwissProt Number: O08599

Rat Gene ID: 25558

Rat SwissProt Number: P61765

Research Use Only