Product Description

Vitronectin Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES7512-50, ES7512-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: VTN, Vitronectin, VN, S-protein, Serum-spreading factor, V75

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human Vitronectin. AA range:209-258

Isotype: IgG

Target: Vitronectin

Specificity: Vitronectin Polyclonal Antibody detects endogenous levels of Vitronectin protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in the retina pigment epithelium (at protein level) (PubMed:25136834), Expressed in plasma (at protein level) (PubMed:2448300), Expressed in serum (at protein level) (PubMed:29567995),

Observed Band (KD): 55kD

Fields: PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Complement and coagulation cascades, Human papillomavirus infection, Proteoglycans in cancer

Function: Domain: The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin
Function: Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity
Function: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway
PTM: It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both
PTM: N- and O-glycosylated
PTM: Phosphorylation on Thr-69 and Thr-76 favors cell

Subcellular Location: Secreted, extracellular space, Parasitophorous vacuole (Microbial infection) In Pfalciparum-infected red blood cells, VTN internalization is detected at the early trophozoite stage (PubMed:29567995) Colocalizes with SERA5 at the schizont stage and with SERA5 P47 at the merozoite surface (PubMed:29567995)

Storage and Stability: -20°C/1 year

Gene Name: VTN

Protein Name: Vitronectin

Mouse Gene ID: 22370

Mouse SwissProt Number: P29788

Research Use Only