Product Description

VP16 tag Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65868-50, BS65868-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: HSV evades the immune system through interference with MHC class I antigen presentation on the cell surface, by blocking TAP or the transporter associated with antigen processing induced by the secretion of ICP-47 by HSV. In the host cell, TAP transports digested viral antigen epitope peptides from the cytosol to the endoplasmic reticμlum, allowing these epitopes to be combined with MHC class I molecμles and presented on the surface of the cell. Viral epitope presentation with MHC class I is a requirement for activation of cytotoxic T-lymphocytes (CTLs), the major effectors of the cell-mediated immune response against virally-infected cells. ICP-47 prevents initiation of a CTL-response against HSV, allowing the virus to survive for a protracted period in the host.

Category: Primary Antibody

Reactivity: Human herpesvirus 1

Host: Rabbit

Applications: WB

Alternate Names: VP16_HHV1F,μl48, Tegument protein VP16, Alpha trans-inducing protein, Alpha-TIF, ICP25, Vmw65

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from HSV-1 VP16:391-490/490aa

Dilution: WB=1:500-2000

Purification: affinity purified by Protein A

Specificity: VP16 tag Polyclonal Antibody detects endogenous levels of VP16 tag protein.

Molecular Weight: ~51 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -41°C long term. Avoid freeze-thaw cycles.

SwissProt: P04486

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only