Product Description

VPS18 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES12348-50, ES12348-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human VPS18 AA range: 778-828

Isotype: IgG

Target: VPS18

Specificity: This antibody detects endogenous levels of VPS18 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitous, Expression was highest in heart and low in lung,

Molecular Weight (Da): 107kD

Fields: Salmonella infection

Function: Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes
Similarity: Belongs to the VPS18 family
Similarity: Contains 1 clathrin repeat
Similarity: Contains 1 RING-type zinc finger
Subcellular Location: Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes
Subunit: Interacts with HOOK1 (By similarity). Large hetero-oligomeric complex together with VPS11, VPS16 and VPS33A. Interacts with STX7
Tissue Specificity: Ubiquitous. Expression was highest in heart and low in lung

Subcellular Location: Late endosome membrane, Peripheral membrane protein, Cytoplasmic side Lysosome membrane, Peripheral membrane protein, Cytoplasmic side Early endosome Cytoplasmic vesicle, autophagosome Cytoplasmic vesicle, clathrin-coated vesicle Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes

Storage and Stability: -20°C/1 year

Gene Name: VPS18 KIAA1475

Protein Name: VPS18

Mouse Gene ID: 228545

Mouse SwissProt Number: Q8R307

Research Use Only