X11γ (R401) Polyclonal Antibody-BS3806

X11γ (R401) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS3806-50, BS3806-100

Sizes: 50µl, 100µl

Swiss-Prot: O96018

Host: Rabbit

Reactivity: Human

Applications: IHC

Background: Amyloid β precursor protein (β APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The amyloid β precursor is known to interact with several proteins, including the G heterotrimetric protein, APP-BP1, and X11. The neuronal, transmembrane protein X11 is known to bind to the amyloid β precurser protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular β APP and slowing β APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of β APP. Multiple splice varitents of X11 have been identified, including X11 α, β and γ (also known as Mint 1, 2 and 3, respectively).

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: X11γ (R401) polyclonal antibody detects endogenous levels of X11γ protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of X11γ (R401) pAb in paraffin-embedded human lung carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 61 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Amyloid beta A4 precursor protein-binding family A member 3; Adapter protein X11gamma; Neuron-specific X11L2 protein; Neuronal Munc18-1-interacting protein 3; Mint-3; APBA3; MINT3; X11L2

Immunogen: Synthetic peptide, corresponding to amino acids 371-420 of Human X11γ.

Conjugate: Unconjugated

Modification: Unmodified