Product Description

YMEL1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES12257-50, ES12257-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human YMEL1 AA range: 136-186

Isotype: IgG

Target: YMEL1

Specificity: This antibody detects endogenous levels of YMEL1 at Human/Mouse/Rat

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.353% sodium azide.

Expression: High expression in cardiac and skeletal muscle mitochondria,

Observed Band (KD): 85kD

Function: Cofactor: Binds 1 zinc ion per subunit
Function: Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism
Similarity: In the C-terminal section, belongs to the peptidase M41 family
Similarity: In the N-terminal section, belongs to the AAA ATPase family

Subcellular Location: Mitochondrion inner membrane Mitochondrion

Storage and Stability: -20°C/1 year

Gene Name: YME1L1 FTSH1 YME1L UNQ1868/PRO4304

Protein Name: YMEL1

Mouse Gene ID: 27377

Mouse SwissProt Number: O88967

Rat SwissProt Number: Q925S8

Research Use Only