ZBTB33 Polyclonal Antibody Sizes: 60μL, 120μL, 200μL Catalogue Numbers: E-AB-52062-60, E-AB-52062-120, E-AB-52062-200 Citations, Manuals and MSDS Available upon request. Abbreviation: ZBTB33 Target Synonym: Kaiso; Kaiso protein; Kaiso transcription factor; KAISO; Transcriptional regulator Kaiso; ZBTB 33; Zbtb33; Zinc finger and BTB domain containing 33; Zinc finger and BTB domain-containing protein 33; Zinc finger transcription factor Kaiso; ZNF 348; ZNF Kaiso; ZNF348 Research Areas: Cancer, Epigenetics and Nuclear Signaling Conjugation: Unconjugated Host: Rabbit Species Reactivity: Human Application: IHC, ELISA Isotype: IgG Clonality: Polyclonal UNIProt ID: Q86T24 Background: This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified. Concentration: 0.9 mg/mL Immunogen: Synthetic peptide of human ZBTB33 Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 Purification Method: Antigen affinity purification Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000 Storage: -20°C/One year. Avoid freeze / thaw cycles. Shipping: Ice bag Research Use Only