ZDH17 Polyclonal Antibody - BT-AP15622

ZDH17 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP15622-20, BT-AP15622-50, BT-AP15622-100

Citations, Manuals and MSDS Available upon request.

Background: Catalytic activity:Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.,The DHHC domain is required for palmitoyltransferase activity.,Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May be involved in the NF-kappa-B signaling pathway. Has transforming activity.,miscellaneous:The early and prominent pathology of HD is observed in the medium spiny neurons that project into the globus.,Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.,Contains 1 DHHC-type zinc finger.,Contains 5 ANK repeats.,subunit:Binds HD. This interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease.,tissue specificity:Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney.,

Research Areas: Epigenetics and nuclear signaling

Target Protein: ZDHHC17

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Palmitoyltransferase ZDHHC17

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q8IUH5; Mouse: Q80TN5

Synonyms: Palmitoyltransferase ZDHHC17;EC 2.3.1.-;Huntingtin yeast partner H;Huntingtin-interacting protein 14;HIP-14;Huntingtin-interacting protein 3;HIP-3;Huntingtin-interacting protein H;Putat

GeneID: Human: 23390

Research Use Only