Product Description

ZFYV1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES12205-50, ES12205-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human ZFYV1 AA range: 318-368

Isotype: IgG

Target: ZFYV1

Specificity: This antibody detects endogenous levels of ZFYV1 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: [Isoform 2]: Highly expressed in heart, Also detected in the testis,, [Isoform 1]: Expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney, Highly expressed in heart,

Molecular Weight (Da): 85kD

Fields: Autophagy - animal, Pathways of neurodegeneration - multiple diseases

Function: Sequence Caution: Translated as Trp
Similarity: Contains 2 FYVE-type zinc fingers
Subcellular Location: Resides predominantly in the cisternal stacks of the Golgi
Subunit: Binds to phosphatidylinositol-3-phosphate (PtdIns3P) through its FYVE-type zinc finger
Tissue Specificity: Isoform 1 was expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Both isoforms, 1 and 2 showed a high expression in heart. Isoform 2 is also detected in the testis

Subcellular Location: Golgi apparatus, Golgi stack Golgi apparatus Endoplasmic reticulum Lipid droplet Preautophagosomal structure Mitochondrion Resides predominantly in the cisternal stacks of the Golgi (PubMed:11256955) Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum (PubMed:22178386) During starvation conditions, localizes to omegasomes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures (PubMed:31293035, PubMed:25876663) Localizes to lipid droplets in the presence of oleic acid (PubMed:31293035, PubMed:30970241)

Storage and Stability: -20°C/1 year

Gene Name: ZFYVE1 DFCP1 KIAA1589 TAFF1 ZNFN2A1 PP10436

Protein Name: ZFYV1

Mouse Gene ID: 217695

Mouse SwissProt Number: Q810J8

Research Use Only