Product Description

Zic1/2/3/4/5 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES7539-50, ES7539-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse

Host: Rabbit

Applications: IF, ELISA

Alternate Names: ZIC1, ZIC, ZNF201, Zinc finger protein ZIC 1, Zinc finger protein 201, Zinc finger protein of the cerebellum 1, ZIC2, Zinc finger protein ZIC 2, Zinc finger protein of the cerebellum 2, ZIC3, ZNF203, Zinc finger protein ZIC 3, Zinc finger p

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human ZIC1/2/3/4/5. AA range:281-330

Isotype: IgG

Target: Zic1/2/3/4/5

Specificity: Zic1/2/3/4/5 Polyclonal Antibody detects endogenous levels of Zic1/2/3/4/5 protein.

Dilution: Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: CNS, A high level expression is seen in the cerebellum, Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer, Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined,

Molecular Weight (Da): 55kD

Function: Function: May play a role in cerebellar development
Similarity: Belongs to the GLI C2H2-type zinc-finger protein family
Similarity: Contains 5 C2H2-type zinc fingers
Tissue Specificity: CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined

Subcellular Location: Nucleus Cytoplasm Localizes in the cytoplasm in presence of MDFIC overexpression

Storage and Stability: -20°C/1 year

Gene Name: ZIC1

Protein Name: Zinc finger protein ZIC 1

Mouse Gene ID: 22771/22773/22774

Research Use Only