Product Description

ZIM2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES12202-50, ES12202-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: In human, ZIM2 and PEG3 (GeneID:5178) are two distinct genes that share a set of 5' exons and have a common promoter, and both genes are paternally expressed. Alternative splicing events connect the shared exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. This is in contrast to mouse and cow, where ZIM2 and PEG3 genes do not share exons in common, and the imprinting status of ZIM2 is also not conserved amongst mammals. Additional 5' alternatively spliced transcripts encoding the same protein have been found for the human ZIM2 gene. [provided by RefSeq, Oct 2010],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human ZIM2 AA range: 50-100

Isotype: IgG

Target: ZIM2

Specificity: This antibody detects endogenous levels of ZIM2 at Human

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Highest levels of expression in adult testis, modest levels in fetal kidney and brain,

Molecular Weight (Da): 58kD

Function: Function: Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between TP53/p53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells
Function: May be involved in transcriptional regulation
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 1 KRAB domain
Similarity: Contains 1 SCAN box domain
Similarity: Contains 12 C2H2-type zinc fingers
Similarity: Contains 5 C2H2-type zinc fingers
Subunit: Homodimer. Interacts with SIAH1A and SIAH2. Interacts with TRAF2
Tissue Specificity: Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and utreus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is fou

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: ZIM2 ZNF656

Protein Name: ZIM2

Research Use Only