Product Description

ZO-1 Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS46078-50, BS46078-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regμlates adherens junctions. Tight junctions regμlate the movement of ions and macromolecμles between endothelial and epithelial cells. The mμltidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing resμlts in mμltiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC, ICC/IF, FC

Alternate Names: TJP1, ZO1, Tight junction protein ZO-1, Tight junction protein 1

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant protein of human ZO-1

Dilution: IHC: 1:200-1:500 ICC/IF: 1:100 FC: 1:50

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 195 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q07157

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only