Product Description

α-SMA Rabbit Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS9908M-50, BS9908M-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P62736

Host: Rabbit

Reactivity: Human, Mouse, Rat, Zebra fish

Applications: WB, IHC FC

All Applications: WB: 1:1000-1:5000
IHC: 1:50-1:200
FC: 1:50-1:100

Background: Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.

Purification and Purity: Protein A affinity purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This antibody detects endogenous levels of α-SMA and does not cross-react with related proteins.

Bioworld Molecular Weight: ~ 42 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of α-SMA Rabbit mAb at 1:1000 dilution
Lane 1: A549 whole cell lysate
Lane 2: Hela whole cell lysate
Lane 3: NIH/3T3 whole cell lysate
Lane 4: The heart tissue lysate of Mouse, Immunohistochemical analysis of paraffin-embedded human lung tissue using anti-α-SMA antibody. Counter stained with hematoxylin.

Alternative Name: ACTA2; AAT6; ACTSA; MYMY5; Actin, aortic smooth muscle; Alpha-actin-2; Cell growth-inhibiting gene 46 protein; alpha-SMA; a-SMA; aSMA; SMA-alpha;

Immunogen: Recombinant antibody.

Conjugate: Unconjugated

Modification: Unmodified