β-Arrestin 1 (phospho-Ser412) Rabbit Polyclonal Antibody - RA36694

β-Arrestin 1 (phospho-Ser412) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA36694-50, RA36694-100

Citations, Manuals and MSDS Available upon request.

Background: arrestin beta 1 (ARRB1) Homo sapiens Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:1000-2000

Alternative Names: Beta-arrestin-1 (Arrestin beta-1)

Applications: WB

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 408

Protein MW (KDa): 47

SWISS: P49407

Source: Rabbit

Research Use Only