14-3-3 ε Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA21457-50, RA21457-100
Citations, Manuals and MSDS Available upon request.
Background: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon (YWHAE) Homo sapiens This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008],
Condition: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Storage Instructions: -20°C/1 year
Recommended dilutions: WB: 1:1000 IHC:1:200-500
Alternative Names: YWHAE; 14-3-3 protein epsilon; 14-3-3E; YM3355
Applications: WB; IHC-p; IF (paraffin section)
Species Cross-Reactivity: Mouse; Rat
GeneID (Human): 7531
Protein MW (KDa): 28
SWISS: P62258
Source: Rabbit
Research Use Only