14-3-3 sigma (Phospho Ser186) Rabbit Polyclonal Antibody
Sizes: 20μL, 50μL, 100μL
Catalogue Numbers: BT-AP00496-20, BT-AP00496-50, BT-AP00496-100
Citations, Manuals and MSDS Available upon request.
Background: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners| usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17| regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.|p53-regulated inhibitor of G2/M progression.|Belongs to the 14-3-3 family.|subcellular location:May be secreted by a non-classical secretory pathway.|subunit:Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7| EIF4A1| ARHGAP1| VPS26A| VPS29| VPS35 and SFN.|tissue specificity:Present mainly in tissues enriched in stratified squamous keratinising epithelium.|
Research Areas: Neuroscience; Signal transduction; Stem cells
Target Protein: SFN
Applications: WB, ELISA
Reactivity: Human, Mouse
Clonality: Polyclonal
Host: Rabbit
Isotype: IgG
Full Product Name: Stratifin
Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189
Storage: -20°C for 1 year
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration: 1 mg/ml
Molecular Weight (Da): 27280
UniProt Accession: Human: P31947; Mouse: O70456
Synonyms: Stratifin; 14-3-3 protein sigma; Epithelial cell marker protein 1; Stratifin
GeneID: Human: 2810; Mouse: 55948
Research Use Only