2B1F Polyclonal Antibody
Sizes: 20μL, 50μL, 100μL
Catalogue Numbers: BT-AP08347-20, BT-AP08347-50, BT-AP08347-100
Citations, Manuals and MSDS Available upon request.
Background: HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB)| both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes| dendritic cells| macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney t
Research Areas: Immunology
Target Protein: HLA-DRB1
Applications: WB, ELISA
Reactivity: Human, Rat, Mouse
Clonality: Polyclonal
Host: Rabbit
Isotype: IgG
Full Product Name: HLA class II histocompatibility antigen| DRB1-15 beta chain
Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189
Storage: -20°C for 1 year
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration: 1 mg/ml
UniProt Accession: Human: P01911
Synonyms: HLA class II histocompatibility antigen; DRB1-15 beta chain (DW2.2/DR2.2;MHC class II antigen DRB1*15)
GeneID: Human: 3123
Research Use Only