3HAO rabbit pAb
Sizes: 50μL, 100μL
Catalogue Numbers: ES9308-50, ES9308-100
Citations, Manuals and MSDS Available upon request.
Background: 3-Hydroxyanthranilate 3, 4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008],
Source: Rabbit
Applications: WB; ELISA
Dilution: WB 1:500-2000 ELISA 1:5000-20000
Reactivity: Human; Mouse; Rat
Immunogen: Synthesized peptide derived from human protein . at AA range: 30-110
Storage and Stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band (KD): 31kD
Human Gene ID: 23498
Human SWISS Prot NO: P46952
Subcellular Location: Cytoplasm, cytosol.
Research Use Only