4E-BP1 (Phospho-Thr37/46) Rabbit Polyclonal Antibody
Sizes: 20μL, 50μL, 100μL
Catalogue Numbers: BT-AP00280-20, BT-AP00280-50, BT-AP00280-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Research Areas: Epigenetics and nuclear signaling; Metabolism
Target Protein: EIF4EBP1
Applications: WB
Reactivity: Human, Mouse, Rat
Clonality: Polyclonal
Host: Rabbit
Isotype: IgG
Full Product Name: 4E-BP1
Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189
Storage: -20°C for 1 year
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration: 1 mg/ml
UniProt Accession: Human: Q13541; Mouse: Q60876; Rat: Q62622
Synonyms: 4E-BP1; 4EBP1; Eif4ebp1; PHASI; eIF4E binding protein 1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I)
GeneID: Human: 1978; Mouse: 13685; Rat: 116636
Research Use Only