Product Description

5-LO (phospho Ser523) Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA21506-50, RA21506-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: arachidonate 5-lipoxygenase (ALOX5) Homo sapiens This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5 (S)-hydroperoxy-6-trans-8, 11, 14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5 (S)-trans-7, 9-trans-11, 14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],

Reactivity: Human, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: ALOX5, LOG5, Arachidonate 5-lipoxygenase, 5-LO, 5-lipoxygenase

Clonality: Polyclonal

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Molecular Weight: 77

Protein Molecular Weight (kDa): 77

Storage: -20°C/1 year

Human Gene ID: 240

Human SwissProt Number: P09917

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only