a-actinin Monoclonal Antibody (4A12)
Size: 50μL, 100μL
Catalogue Numbers: RA10707-50, RA10707-100
Citations, Manuals and MSDS Available upon request.
Background: actinin alpha 1 (ACTN1) Homo sapiens Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions: -20°C/1 year
Applications: IHC-p; IF (paraffin section)
Species Cross-Reactivity: Human; Rat; Mouse
GeneID (Human): 87
Protein MW (KDa): 103
SWISS: P12814
Source: Mouse
Research Use Only