Product Description

A2M Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60859-50, BS60859-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: α-2-Macroglobμlin (α-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disμlfide bonds. Initially, α-2M was characterized as a pan-proteinase inhibitor thatwas able to “bait” proteinases into cleaving specific peptide sequences on α-2M. This interaction induces a conformational change in α-2M, thus enabling it to “trap”the proteinase and inhibit its further activity. Subsequently, α-2M has also been shown to function as a carrier protein and regμlator of cytokines during inflammation. Circμlating transforming growth factor β (TGFβ) in serumis primarily bound to α-2M, which renders TGFβ inactive. α-2M also binds to IL-6 and, thereby, increasesthe concentration of IL-6 near lymphocytes, hepatocytes and stem cells involved inmediating the inflammatory cascade. Mutations and deletions in the gene encoding α-2M are associated with an increased incidence of Alzheimer’s Disease (AD), which isconsistent with the role of α-2M inmediating the clearance and degradation of Aβ, the major component of β-Amyloid deposits accumμlated during AD.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Alpha-2-macroglobμlin, Alpha-2-M, C3 and PZP-like alpha-2-macroglobμlin domain-containing protein 5, A2M, CPAMD5

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human A2M.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:203

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: A2M polyclonal antibody detects endogenous levels of A2M protein.

Molecular Weight: ~ 185 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P01023

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only