Product Description

AANAT Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60541-50, BS60541-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: AANAT (Aralkylamine N-acetyltransferase), also called Serotonin N-acetyltransferase (SNAT) or Serotonin acetylase, is a member of the acetyltransferase superfamily. It is almost exclusively expressed in the pineal gland and the retina. AANAT activity is high at night and low during the day due to the 10 to 100-fold increase in the amount of active AANAT at night. Retinal exposure to light causes cAMP levels to decrease in photoreceptor cells and, as a resμlt, AANAT is targeted for degradation by proteasomal proteolysis. AANAT plays an important role as the rate limiting enzyme in melatonin synthesis. It is responsible for catalyzing the N-acetylation of serotonin to N-acetylserotonin, which is then converted to melatonin by hydroxyindole-O-methyltransferase. Melatonin is an important hormone that is involved in many physiological processes including immune function, seasonal reproduction, retinal physiology and circadian entrainment.

Category: Primary Antibody

Reactivity: Human, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Serotonin N-acetyltransferase, Serotonin acetylase, Aralkylamine N-acetyltransferase, AA-NAT, AANAT, SNAT

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human AANAT

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: AANAT polyclonal antibody detects endogenous levels of AANAT protein.

Molecular Weight: ~ 23 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q16613

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only