ABCB7 Polyclonal Antibody
Catalogue Numbers: BS5594-50, BS5594-100
Sizes: 50µl, 100µl
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: O75027
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
All Applications: WB: 1:500~1:1000
Background: The peroxisomal membrane contains several ATP-binding cassette (ABC) transporters, ABCD1–4 that are known to be present in the human peroxisome membrane. All four proteins are ABC half-transporters, which dimerize to form an active transporter. A mutation in the ABCD1 causes X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder which affects lipid storage. ABCD2 in mouse, is expressed at high levels in the brain and adrenal organs, which are adversely affected in X-ALD. The peroxisomal membrane comprises 2 quantitatively major proteins, PMP22 and ABCD3. ABCD3 is associated with irregularly shaped vesicles which may be defective peroxisomes or peroxisome precursors. ABCD4 localizes to peroxisomes. ABCB7 is a half-transporter involved in the transport of heme from the mitochondria to the cytosol and maps to human chromosome Xq13.1-q13.3.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: ABCB7 polyclonal antibody detects endogenous levels of ABCB7 protein.
Extra Notes: Western blot (WB) analysis of ABCB7 polyclonal antibody at 1:500 dilution
Lane1:Hela cell lysate
Lane2:Raw264.7 cell lysate
Lane3:PC12 cell lysate
Bioworld Molecular Weight: ~ 95 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein; ABC7; ABCB-7
Immunogen: Synthetic peptide, corresponding to amino acids 707-752 of Human ABCB7.
Conjugate: Unconjugated
Modification: Unmodified