ABCB7 Polyclonal Antibody - BT-AP00094

ABCB7 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP00094-20, BT-AP00094-50, BT-AP00094-100

Citations, Manuals and MSDS Available upon request.

Background: The membrane-associated protein encoded by ABCB7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ATP binding cassette subfamily B member 7 is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. ABCB7 encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in ABCB7 have been associated with mitochondrial iron accumulation and isodicentric (X) (q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for ABCB7.

Research Areas: Signal Transduction; Metabolism

Target Protein: ABCB7

Applications: WB, IHC-p, ELISA

Reactivity: Human

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: ABCB7 Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 82641

UniProt Accession: Human: O75027; Mouse: Q61102

Synonyms: ABCB7; ABC7; ATP-binding cassette sub-family B member 7; mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein

GeneID: Human: 22

Research Use Only