ABCC8 Polyclonal Antibody - BT-AP14026

ABCC8 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP14026-20, BT-AP14026-50, BT-AP14026-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1| MDR/TAP| MRP| ALD| OABP| GCN20| White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy| an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II| an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for

Research Areas: Cancer; Metabolism; Signal transduction; Cardiovascular

Target Protein: ABCC8

Applications: WB, ELISA

Reactivity: Human, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: ATP-binding cassette sub-family C member 8

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q09428; Rat: Q09429

Synonyms: ATP-binding cassette sub-family C member 8;Sulfonylurea receptor 1

GeneID: Human: 6833

Research Use Only