Product Description

ABCG2 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA21550-50, RA21550-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: ATP binding cassette subfamily G member 2 (Junior blood group) (ABCG2) Homo sapiens The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: IF/ICC, WB, IHC-p, ELISA

Alternate Names: ABCG2, ABCP, BCRP, BCRP1, MXR, ATP-binding cassette sub-family G member 2, Breast cancer resistance protein, CDw338, Mitoxantrone resistance-associated protein, Placenta-specific ATP-binding cassette transporter, CD338

Clonality: Polyclonal

Dilution: IF: 1:50-200 Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.

Molecular Weight: 75

Protein Molecular Weight (kDa): 75

Storage: -20°C/1 year

Human Gene ID: 9429

Human SwissProt Number: Q9UNQ0

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only