Abl1/2 (phospho Tyr393/439) Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA20866-50, RA20866-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1) Homo sapiens This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t (9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [pr Reactivity: Human, Mouse Host: Rabbit Applications: WB, IHC-p, IF/ICC, ELISA Alternate Names: ABL1, ABL, JTK7, Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, ABL2, ABLL, ARG, Abelson tyrosine-protein kinase 2, Abelson murine leukemia vira Clonality: Polyclonal Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. Molecular Weight: 125 (200kd BCR-ABL complex） Protein Molecular Weight (kDa): 125 (200kd BCR-ABL complex） Storage: -20°C/1 year Human Gene ID: 25/27 Human SwissProt Number: P00519/P42684 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only