ABL2 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90015-50, BS90015-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P42684(Human) Q4JIM5(Mouse) Unigene:69847(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, FC
All Applications: WB:1:1,000-1:2,000
FC:1:50-1:100
Background: The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including chronic myelocytic leukemia (CML), in which it undergoes a (9;22) chromosomal translocation and produces the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein tyrosine kinase. The related protein tyrosine kinase Arg, also designated Abl2, contains an SH2 and an SH3 domain. Arg has been shown to interact with and to phosphorylate c-Crk.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: ABL2 polyclonal antibody detects endogenous levels of ABL2 protein.
Bioworld Molecular Weight: 128 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of ABL2 on different lysates using anti-ABL2 antibody at 1/1,000 dilution.
Positive control:
Lane 1: Hela
Lane 2: PC-12
Lane 3: Jurkat, Flow cytometric analysis of Raji cells with ABL2 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody
Alternative Name: ABL2, Abelson murine leukemia viral oncogene homolog 2, Abelson related gene protein, Abelson tyrosine-protein kinase 2, Abelson-related gene protein, ABL2, ABL2, ABLL, ARG, Tyrosine kinase ARG, Tyrosine protein kinase ABL2, Tyrosine-protein kinase ARG, v abl Abelson murine leukemia viral oncogene homolog 2,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified