ACE Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90020-50, BS90020-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P12821(Human) P09470(Mouse)
Host: Rabbit
Reactivity: Human, Mouse
Applications: WB, IHC FC
All Applications: WB:1:500-1:2,000
IHC:1:100-1:500
FC:1:50-1:100
Background: Angiotensin-converting enzyme (ACE) is a carboxy-terminal dipeptidyl exo-peptidase that converts Angiotensin I to the potent vasopressive hormone, Angiotensin II. There are two isoforms of ACE, the pulmonary ACEP and the testicular ACET. ACEP is a glycoprotein expressed in vascular endothelial cells of the lung, liver, adrenal cortex, pancreas, kidney and spleen. The ACET isoform is expressed exclusively in adult testis by developing sperm cells, specifically, late pachytene spermatocytes. Additionally, ACE inactivates bradykinin, a vasodepressor peptide, and is involved in fluid/electrolyte homeostasis. Although it bears significant sequence homology to ACE, ACE2 shows a more restricted pattern of expression. ACE is expressed ubiquitously throughout the vasculature while ACE2 is expressed only in cardiac, renal and testicular cells.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: ACE polyclonal antibody detects endogenous levels of ACE protein.
Bioworld Molecular Weight: 160 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of ACE on human lung (1) and mouse kidney (2) cell lysate using anti-ACE antibody at 1/1,000 dilution., Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-ACE antibody. Counter stained with hematoxylin.
Alternative Name: ACE, DCP, DCP1, ACE 1, ACE, ACE T, ACE, ACE1, Angiotensin converting enzyme somatic isoform, Angiotensin converting enzyme testis specific isoform, Angiotensin I converting enzyme 1, Angiotensin I converting enzyme, Angiotensin I converting enzyme peptidyl dipeptidase A 1, angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript, Angiotensin-converting enzyme, Carboxycathepsin, CD 143, CD143, CD143 antigen, DCP 1, DCP, DCP1, Dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, Kininase II, MGC26566, MVCD3, Peptidase P, Peptidyl dipeptidase A, soluble form, Testicular ECA,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified