ACE2 Rabbit pAb - ES20857

ACE2 Rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20857-50, ES20857-100

Citations, Manuals and MSDS Available upon request.

Background: angiotensin I converting enzyme 2 (ACE2) Homo sapiens The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.

Alternate Name: Angiotensin-converting enzyme 2 (EC 3.4.17.23) (ACE-related carboxypeptidase) (Angiotensin-converting enzyme homolog) (ACEH) (Metalloprotease MPROT15) [Cleaved into: Processed angiotensin-converting enzyme 2]

Source: Rabbit

Applications: IHC; WB

Dilution: IHC-p 1:50-200, WB 1:1000-2000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human ACE2 AA range: 425-475

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 120-135kD

Human Gene ID: 59272

Human SWISS Prot NO: Q9BYF1

Subcellular Location: [Processed angiotensin-converting enzyme 2]: Secreted.; Cell membrane; Single-pass type I membrane protein. Cytoplasm. Cell projection, cilium. Apical cell membrane. Detected in both cell membrane and cytoplasm in neurons.; [Isoform 2]: Apical cell membrane.

Research Use Only