Acetyl-CoA Carboxylase Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A23986-20, A23986-100
Citations, Manuals and MSDS Available upon request.
Background: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 265kDa/276kDa
Observed Molecular Weight: 280kDa
Immunogen: Synthetic peptide .
Species: Human
GeneID: 31/32
SWISS: Q13085/O00763
Alternate Names: ACC; ACAC; ACC1; ACCA; Acac1; hACC1; ACACAD; ACCalpha; ACACalpha; Acetyl-CoA Carboxylase
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:1000 - 1:5000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cardiovascular; Lipids / Lipoproteins、Fatty Acids Synthesis; Signal Transduction；Metabolism；Mitochondrial；Cancer Metabolism.
NCBI Alias: ACACA/ACACB
Research Use Only