Product Description

Acetyl Lysine Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB65867-50, MB65867-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Acetylation of lysine, like phosphorylation of serine, threonine or tyrosine, is an important reversible modification controlling protein activity. The conserved amino-terminal domains of the four core histones (H2A, H2B, H3, and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs). Signaling resμlting in acetylation/deacetylation of histones, transcription factors, and other proteins affects a diverse array of cellμlar processes including chromatin structure and gene activity, cell growth, differentiation, and apoptosis. Recent proteomic surveys suggest that acetylation of lysine residues may be a widespread and important form of posttranslational protein modification that affects thousands of proteins involved in control of cell cycle and metabolism, longevity, actin polymerization, and nuclear transport. The regμlation of protein acetylation status is impaired in cancer and polyglutamine diseases, and HDACs have become promising targets for anti-cancer drugs currently in development.

Category: Primary Antibody

Reactivity: All

Host: Mouse

Applications: WB, IHC

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Acetylated

Immunogen: Purified protein corresponding to Acetyl Lysine.

Dilution: WB (1/1000 - 1/2000), IHC (1/200 - 1/500)

Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes endogenous levels of Acetyl Lysine protein.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only