Acetyl NF kB P65 (K314/K315) (5G11) Mouse mAb - EM1377

Acetyl NF kB P65 (K314/K315) (5G11) Mouse mAb

Sizes: 50μL, 100μL

Catalogue Numbers: EM1377-50, EM1377-100

Citations, Manuals and MSDS Available upon request.

Background: NFkB p65 is ubiquitinated leading to its proteosomal degradation, which is required for termination of the NFkB response. Phosphorylation of NFkB p65 on S536 stimulates acetylation of K310 by CBP, enhancing transcriptional activity. NFkB p65 is also acetylated at K122, enhancing DNA binding and impairing the interaction with NFKBIA. The protein is deacetylated by HDAC3. Invasion of a host by a pathogen is frequently associated with the activation of NF-kB, which coordinates various aspects of immune function required for resistance to infection.

Alternate Name: NF kappa B p65, NFKB3, p65, p65 NF kB, RELA, TF65, Transcription Factor p65

Source: Mouse

Applications: IHC

Dilution: IHC 1:100-200

Reactivity: Human, Mouse, Rat

Immunogen: Synthetic Peptide

Storage and Stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality: Monoclonal

Isotype: IgG1

Concentration: 1mg/mL

Observed Band (KD): 65kDa

Human Gene ID: 5970

Human SWISS Prot NO: Q04206

Subcellular Location: Cytoplasm,  Nucleus

Research Use Only